Search results for "CYTOCHROME P 450"

showing 10 items of 10 documents

Beta-apo-8'-carotenal, but not beta-carotene, is a strong inducer of liver cytochromes P4501A1 and 1A2 in rat

1996

35 ref.; International audience

ALIMENTATION DES ANIMAUXRAT[SDV.BID]Life Sciences [q-bio]/BiodiversityCYTOCHROME P 450[SDV.BID] Life Sciences [q-bio]/Biodiversity

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Dietary carotenoids inhibit aflatoxin B1-induced liver preneoplastic foci and DNA damage in the rat: Role of the modulation of aflatoxin B1 metabolism

1998

To study the effects of carotenoids on the initiation of liver carcinogenesis by aflatoxin B1 (AFB1), male weanling rats were fed beta-carotene, beta-apo-8'-carotenal, canthaxanthin, astaxanthin or lycopene (300 mg/kg diet), or an excess of vitamin A (21000 RE/kg diet), or were injected i.p. with 3-methylcholanthrene (3-MC) (6 x 20 mg/kg body wt) before and during i.p. treatment with AFB1 (2 x 1 mg/kg body wt). The rats were later submitted to 2-acetylaminofluorene treatment and partial hepatectomy, and placental glutathione S-transferase-positive liver foci were detected and quantified. The in vivo effects of carotenoids or of 3-MC on AFB1-induced liver DNA damage were evaluated using diff…

MaleVitaminCancer Researchmedicine.medical_specialtyAflatoxinAflatoxin B1DNA damage[SDV]Life Sciences [q-bio]Biology03 medical and health scienceschemistry.chemical_compoundLiver Neoplasms Experimental0302 clinical medicineAstaxanthinInternal medicinemedicineAnimalsAnticarcinogenic AgentsCanthaxanthinRats WistarVitamin ACYTOCHROME P 450CarotenoidSerum Albumin030304 developmental biologychemistry.chemical_classification0303 health sciencesRetinolGeneral MedicineCarotenoidsDietRats3. Good health[SDV] Life Sciences [q-bio]Endocrinologychemistry030220 oncology & carcinogenesisCarcinogensMicrosomes LiverRAT2-AcetylaminofluoreneCARCINOGENESEPrecancerous ConditionsDNA DamageMethylcholanthrene

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Induction of cytochrome P450 and/or detoxication enzymes by various extracts or rosemary: description of specific patterns

2001

The ability of rosemary to modulate cytochrome P450 (CYP) and detoxication enzymes in rat liver was evaluated by comparing the effects of dried leaves and leaf extracts with different chemical compositions: essential oil (EO) containing monoterpenes, a dichloromethane extract (DCME) containing phenolic diterpenes and a water-soluble extract (WSE) containing phenolic compounds such as rosmarinic acid and flavonoids. Chemical analyses were done in order to characterize the composition of extracts. Male Wistar rats received the leaves or extracts of rosemary in their diet at 0.5% (w/w) for 2 weeks. The effects of such treatments were evaluated for CYP (1A, 2B, 2E1), glutathione S-transferase (…